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Nocturia Quality-of-Life questionnaire is a useful tool to predict nocturia and a risk of falling in Japanese outpatients: A cross-sectional survey

By T. Yamanishi, M. Fuse, C. Yamaguchi, T. Uchiyama, T. Kamai, S. Kurokawa and T. Morita

International Journal of Urology, Volume 21, Issue 3, March 2014, Pages 289-293

Editor’s comments:
The current study was aimed to investigate the relationships between the Nocturia Quality of Life-questionnaire ( N-QOL), in the Japanese version, and underlying diseases as OAB, Benign Prostatic Enlargement, Hypertension, Cardiovascular diseases and frequency of falling in a large patients’ population. A cross-sectional survey was conducted in Japan, in 15 general hospitals and 80 general clinics, and answers were obtained from 2494 patients (1154 males, 1208 females, and 132 unknown). The included departments were internal medicine, urology, orthopedics, surgery and cardiovascular disease. From the analysis it could be determined that N-QOL score <90 had 63.1% sensitivity and 78.6% specificity for estimating night-time voiding frequency more than twice. A N-QOL score <90 represented a possible criterion for determining nocturia. In addition, it was observed that a cut-off value of N-QOL score ≤80 could show the risk of being about to fall at least once. The Authors concluded that N-QOL is a useful instrument to evaluate the impact of nocturia on daily life and also to assess the risk of bone fracture as a result of nocturia.

Abstract
Objectives

To evaluate the Japanese version of the Nocturia Quality-of-Life questionnaire for prediction of night-time voiding and risk of falling.

Methods
A survey was carried out from October 2008 to June 2009 in outpatients at 15 general hospitals and 80 general clinics in Tochigi, Japan, using the Nocturia Quality-of-Life questionnaire, overactive bladder symptom score and self-administered questionnaires on night-time symptoms (awakening, number of voids, incontinence and falling).

Results
The survey was completed by 2494 participants (1154 men, 1208 women; mean age 63.2 ± 15.1 years). Overactive bladder was diagnosed in 625 participants (25.1%) according to the Japanese overactive bladder guideline using overactive bladder symptom score. Awakening during sleep was reported by 80.1% of the participants, and 70.4% awakened to go to the toilet. The mean Nocturia Quality-of-Life score was 86.8 ± 16.9. The Nocturia Quality-of-Life score was lower in patients with overactive bladder, benign prostatic hyperplasia, diabetes, hypertension and cardiovascular diseases. The Nocturia Quality-of-Life score was significantly decreased in patients with night-time symptoms (P < 0.001). Nocturia Quality-of-Life scores and those for subdomains were correlated with overactive bladder symptom score. Nocturia Quality-of-Life ≤90 had 63.1% sensitivity and 78.6% specificity in indicating night-time voiding more than twice, and Nocturia Quality-of-Life questionnaire ≤80 had 70.2% sensitivity and 79.5% specificity in indicating the probability of falling at least once. Logistic analysis showed that 10-year increase in age and overactive bladder in all participants were significant risk factors for Nocturia Quality-of-Life ≤90.

Conclusions
The Nocturia Quality-of-Life questionnaire represents a useful tool to predict nocturia and risk of falling in Japanese patients.