Welcome

This website is intended for international healthcare professionals with an interest in the treatment of Nocturia. By clicking the link below you are declaring and confirming that you are a healthcare professional. Please answer a few short questions about this resource centre.

You are here

Nocturia, Other Lower Urinary Tract Symptoms and Sleep Dysfunction in a Community-Dwelling Cohort of Men

Martin SA et al.

Urology, Volume 97, November 2016, Pages 219–226

Commentary by Philip Van Kerrebroeck

This study examines the influence of obstructive sleep apnea (OSA) on nocturia, in a population of community-based middle aged to elderly men. Participants were drawn from a randomly selected cohort of men in Adelaide, Australia. In total 708 men (mean: 60.7 [41.6-88.2] years) were included that had polysomnography recordings, complete lower urinary tract symptoms (LUTS) measures (IPSS), without prostate or bladder cancer and/or surgery, and no prior OSA diagnosis. Nocturia was defined as ≥2 voids per main sleep. Unadjusted and multi-adjusted regression models of nocturia were combined with OSA, wake after sleep onset, total sleep period, excessive daytime sleepiness (EDS), and sleep quality (SQ) data, together with socio-demographic, and health-related factors. Men with nocturia (32.2%[n = 65]), were found to have higher levels of OSA wake earlier after sleep onset time(97.2 ± 52.9 minutes), have shorter sleep period (467.3 ± 58.4 minutes), increased EDS(18.2%), and poorer SQ (54.3% ). Multiple-adjusted models showed nocturia was positively associated with OSA, EDS, and poorer SQ. Including other storage and voiding LUTS attenuated the effect of OSA and strengthened the association with EDS, whereas voiding LUTS also strengthened the association with poorer SQ. Men with increasing nocturic frequency spent less time in N2 and rapid eye movement stage sleep. Based on these results the authors conclude that nocturia is strongly associated with OSA in community-based men, and reduces sleep efficiency/SQ, N2, and rapid eye movement sleep time, while increasing EDS. They also indicate that other LUTS increase EDS through non-OSA means.

Abstract

OBJECTIVES:

To examine the influence of obstructive sleep apnea (OSA) on nocturia, controlling for their shared co-morbidities, in a population of community-based middle aged to elderly men.

METHODS:

Participants were drawn from a randomly selected, community-dwelling cohort of men in Adelaide,Australia. Seven hundred and eight men (mean: 60.7 [41.6-88.2] years) who had polysomnographyrecordings, complete lower urinary tract symptoms (LUTS) measures (International Prostate SymptomScore), without prostate or bladder cancer and/or surgery, and no prior OSA diagnosis were selected.Nocturia was defined as ≥2 voids per main sleep. Unadjusted and multi-adjusted regression models ofnocturia were combined with OSA, wake after sleep onset, total sleep period, excessive daytimesleepiness (EDS), and sleep quality (SQ) data, together with socio-demographic, and health-relatedfactors.

RESULTS:

Men with nocturia were found to have higher levels of OSA (32.2% [n = 65]), wake after sleep onsettime (97.2 ± 52.9 minutes), sleep period (467.3 ± 58.4 minutes), EDS (18.2% [n = 37]), and poorer SQ 54.3% [n = 108]). Multiple-adjusted models showed nocturia was positively associated with OSA(odds ratio:1.64, 95% confidence interval [1.03,2.55]), EDS (1.72 [1.01,2.93]), and poorer SQ (1.65[1.10,2.48]). Including other storage and voiding LUTS attenuated the effect of OSA and strengthenedthe association with EDS (2.44 [1.45,4.10] and 2.24 [1.19,4.22]), whereas voiding LUTS alsostrengthened the association with poorer SQ (2.61 [1.63,4.17]). Men with increasing nocturicfrequency spent less time in N2 and rapid eye movement stage sleep.

CONCLUSION:

Nocturia is strongly associated with OSA in community-based men. Nocturia also reduces sleepefficiency/SQ, N2, and rapid eye movement sleep time, while increasing EDS. Other LUTS increaseEDS through non-OSA means.

Ferring Pharmaceuticals LogoMade possible by an
educational grant
from Ferring

World Sleep Day

Search

E-Alert

Subscribe to our E-Alert to stay informed of all new content.

Lecture from the ICS

6th - 9th October 2015

ICS 2015: Nocturia Plenary Satellite Symposium, Montreal, Canada

Program Chair: Philip E. V. Kerrebroeck

Featured Editorial

Defining Nocturnal Polyuria
By Prof. Philip van Kerrebroeck

Best read article

  • Nocturia in older men

    Boris van Doorn, J.L.H. Ruud Bosch

    Maturitas, Volume 71, Issue 1, 2012, pages 8 - 12

The editorial independence of the resource centre is mandatory and recognized by the EAU and Elsevier.
The journal articles, videos and statements published on the resource centre have been selected independently and without influence from Elsevier, European Urology Editors or the sponsor and do not necessarily reflect their opinions or views.

Book on Nocturia!

Nocturia: Causes, Consequences and Clinical Approaches Is the first volume exclusively on the topic of nocturia and is designed to be a comprehensive treatise on the subject.